# transgene copies in genome |
8 |
6 |
Diap3 cochlear expression (fold increase) |
700× |
1100× |
Hearing loss (ABR at 12 and 24 kHz) |
Onset 4–8 weeks Progressive |
Onset by 16 weeks Progressive |
IHC stereociliary defects |
Evident at 4 weeks and progressive |
Evident by 8 weeks and progressive |
Ribbons per IHC |
Progressive loss from 16 weeks to 24 weeks; 46% reduction at 24 weeks |
Mild loss static from 8 to 24 weeks; 22% reduction at 24 weeks |
OHC function (DPOAEs at 12 kHz) |
Preserved at 24 weeks |
Preserved at 24 weeks |
OHC function (DPOAEs at 24 kHz) |
Significant reduction |
Variably preserved |
SGC (Type I neurons) counts |
Normal |
Normal |