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Illustration of the activation mechanism: PDZ1→L3→LD/L1/L3. The R37 of loop L3 interact with G200 of PDZ1 domain which allows Q26 of the loop L3 to interact with the residue I16 of loop LD in the adjacent protease shown in * mark. This may induce remodeling of the proteolytic sites and functional catalytic triad set up between S12 of loop LD and H50 & L52 of loop L1.
