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. Author manuscript; available in PMC: 2013 Feb 18.
Published in final edited form as: Chem Biol Interact. 2011 Feb 15;191(1-3):351–356. doi: 10.1016/j.cbi.2011.02.005

Figure 2. Lens plaque formation in AKR1B1 transgenic lens.

Figure 2

Animals were euthanized at P35 and paraffin sections were produced for H&E staining. (A) A dense cellular plaque was observed at the anterior aspect of lenses from transgenic strain PAR39. (B) Higher magnification of area demarcated in panel A. The dense cellular plaque is indicated by the arrow. (C) Some lenses were embedded in plastic and used to produce thin sections for toluidine blue staining. The lens plaque appears to be separated from surrounding cortical fiber cells and surrounded by large vacuoles (arrows).