Figure 10.

Topographical and cell-type specific regulation of P-ERK by SKF81297, quinpirole, apomorphine, and raclopride in the NAc. Quantification of P-ERK-positive cells among GFP-negative (white bars) and GFP-positive (green bars) neurons in the NAc core (A), in the ventral NAc shell [(B) D2R-expressing MSNs-poor zone and (C) area surrounding the D2R-expressing MSNs-poor zone] and in the caudomedial NAc shell [(D) D2R-expressing MSNs-poor zone; (E) bundle-shaped area; and (F) cone] in Drd2-EGFP mice, 15 min after vehicle (Veh), SKF81297 (SKF), quinpirole (Qui), apomorphine (Apo), and raclopride (Rac) administration. Green squares in diagrams indicate the region analyzed. Data are number of cells per area (see Table A1) and are expressed as means ± SEM (3–5) and were analyzed using one-way ANOVA (see Table A3 for F values). Dunnett's test: ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 veh vs. drugs in Drd2-EGFP negative, °p < 0.05, °°°p < 0.001 veh vs. drugs in Drd2-EGFP positive.