Figure 12.

Regulation of ERK phosphorylation in the caudomedial NAc shell. (A) Triple immunofluorescence for P-ERK (red), GFP (green), and DARPP-32 (blue) in the caudomedial NAc shell of Drd2-EGFP mice treated with vehicle and SKF81297 (5 mg/kg) (A) and raclopride (B). Images are single confocal sections. Scale bar: 200 μm. High magnification of the area delineated by the white squares. Scale bar: 100 μm. Yellow asterisk indicates the D2R-expressing MSNs-poor zone. Yellow arrowheads indicate P-ERK/GFP/DARPP-32 positive neurons.