Figure 9.

Regulation of ERK phosphorylation in the NAc core. Double immunofluorescence for P-ERK (magenta) and GFP (green) in the NAc Core of Drd2-EGFP mice treated with vehicle, SKF81297 (5 mg/kg), quinpirole (1 mg/kg), apomorphine (3 mg/kg), and raclopride (0.3 mg/kg). Scale bar: 200 μm. High magnification of the area delineated by the white dashed square. Yellow arrowheads identify D2R-expressing MSNs that contain P-ERK. Images are single confocal sections. Scale bar: 50 μm. Note that apomorphine-induced ERK phosphorylation in clusters that resemble the striosomal compartment.