Table 2.

Clinical Studies of Right Ventricle Targeted Therapies

Therapy	Design	Population	Major findings	Reference
β-blocker (bisoprolol, carvedilol)	Single-arm, open-label	Patients status-post correction of transposition of the great arteries	Improved symptoms, quality of life, and RV ejection fraction.	Bouallal et al.
β-blocker (metoprolol, atenolol, bisoprolol, propranolol, acebutolol, nodolol)	Prospective cohort study	PAH patients	Did not increase adverse or hemodynamic consequences.	So et al.
β-blocker (metoprolol)	Case report	Portopulmonary hypertension	Caused hemodynamic compromise	Peacock et al.
β-blocker (propranolol, atenolol)	Prospective cohort study	Portopulmonary hypertension	Withdrawal of β-blocker caused improved exercise capacity and hemodynamics	Provencher et al.