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. 2012 Nov 20;2(2):132–143. doi: 10.1242/bio.20123145

Fig. 5. Epidermal growth factor modulates the permeability of the corneal epithelial TJ.

Fig. 5.

(A) Shows that the cldn-1 immunolocalization pattern is strong with punctuated discontinuities in cell cultures maintained in basal medium without EGF, while (B) cells cultured in the presence of 10 ng/ml EGF had a well-defined cell–cell contacts and a typical cldn-1 immunolocalization, with some discontinuities. The highest expression of cldn-1 correlated with (C) high TER values in the EGF-supplemented cultures which showed the tightest epithelial barrier. Effect of EGF was significant (P≤0.005) for 5 duplicated experiments. A,B scale bar = 16 μm.