Table 1.
Baseline characteristics of 402 overweight/obese children according to serum TSH.
| Serum TSH | P value | ||
|---|---|---|---|
| ≤4 mIU/L (n = 314) | >4 mIU/L (n = 88) | ||
| TSH, mIU/L | 2.42 (2.33–2.52) | 4.74 (4.52–4.95) | <0.0001 |
| Age, years | 10.7 (10.3–11.1) | 10.9 (10.0–11.2) | 0.46 |
| Male gender, n (%) | 175 (55.7) | 55 (62.5) | 0.35 |
| Prepubertal, n (%) | 159 (50.6) | 58 (65.9) | 0.56 |
| Weight, Kg | 61 (59–63) | 60 (55–65) | 0.70 |
| Height, cm | 149 (147–152) | 149 (144–153) | 0.80 |
| BMI, Kg/m2 | 26.3 (25.7–26.8) | 26.3 (25.2–27.3) | 0.75 |
| BMI-SDS | 2.0 (1.94–2.2) | 2.0 (1.9–2.2) | 0.80 |
| Waist circumference, cm | 87 (84–90) | 89 (87–90) | 0.26 |
| Systolic blood pressure, mmHg | 109 (107–110) | 110 (107–112) | 0.88 |
| Diastolic blood pressure, mmHg | 69 (68–70) | 70 (67–72) | 0.82 |
| Triglycerides, mg/dL | 99 (90–108) | 119 (103–135) | <0.01 |
| Total cholesterol, mg/dL | 160 (156–165) | 176 (166–186) | <0.01 |
| HDL-C, mg/dL | 47 (46–49) | 45 (43–48) | 0.30 |
| Fasting glucose, mmol/L | 4.71 (4.64–4.78) | 4.67 (4.58–4.75) | 0.48 |
| Insulin, mU/L | 16.0 (15.0–18.0) | 19.3 (16.5–22.0) | <0.05 |
| HOMA-IR values | 3.62 (3.22–4.0) | 4.0 (3.4–4.6) | <0.05 |
| ALT, IU/L | 31 (28–35) | 52 (36–68) | <0.01 |
| GGT, IU/L | 17 (16–19) | 22 (18–26) | <0.01 |
| FT3, pg/mL | 4.26 (4.18–4.35) | 4.35 (4.26–4.42) | 0.14 |
| FT4, ng/dL | 1.18 (1.15–1.22) | 1.18 (1.12–1.22) | 0.76 |
Data are expressed as n (%), mean or geometric mean (95% confidence intervals).
TSH: thyroid-stimulating hormone; BMI: body mass index; BMI-SDS: BMI-SD score; HDL-C: high-density lipoprotein cholesterol; HOMA-IR: homeostasis model assessment of insulin resistance; ALT: alanine aminotransferase; GGT: gamma-glutamyl transferase; FT3: free triiodothyronine; FT4: free thyroxine.