Table 2.
Results of Gene-Based Multivariable Regression Models
| Dataset | Outcome | Gene (Chr) | SNP(s) | Without Local Ancestry | With Local Ancestry | P value of Local Ancestry | ||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| β | SE(β) | P value | β | SE(β) | P value | |||||
| FBPP | SBP | CXADR (21) | rs437470 | 3.17 | 0.830 | 0.0001 | 2.94 | 0.835 | 0.0004 | 0.011 |
| FBPP | DBP | CXADR (21) | rs437470 | 1.70 | 0.460 | 0.0002 | 1.60 | 0.463 | 0.0006 | 0.001 |
| FBPP | BMI | F2RL1 (5) | rs631465 | 3.41 | 1.045 | 0.0011 | 3.71 | 1.056 | 0.0005 | 0.352 |
| ARIC & JHS | SBP | CXADR (21) | rs437470 | 0.27 | 0.499 | 0.5918 | 0.19 | 0.504 | 0.7110 | 0.277 |
| ARIC & JHS | DBP | CXADR (21) | rs437470 | 0.10 | 0.291 | 0.7269 | 0.04 | 0.294 | 0.9005 | 0.134 |
SE: Standard Error. (Chr): Chromosome number. Statistically-significant after adjusting for the total number of genes tested. 51 genes on chromosome (chr) 21 were tested for DBP and SBP (critical p-value = 0.000980392), and 91 genes on chromosome 5 were tested for BMI (critical p = 0.000549451) for the FBPP dataset analyses. All SBP and DBP multivariable models were adjusted for age, age2, sex, BMI, and global ancestry, unless otherwise noted. All BMI multivariable models were adjusted for age, age2, sex, and global ancestry, unless otherwise noted.