Table 4.
Results of Gene-Based Multivariable Regression Models that were Nominally Significant at α = 0.05
Without local ancestry | With local ancestry | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
| ||||||||||
Phenotype | Gene | Chr | SNPs | β | SE(β) | P value | β | SE(β) | P value | P Value of Local Ancestry |
BMI | ATG10 | 5 | rs3734114, rs1864183 | 0.50 | 0.243 | 0.0380 | 0.59 | 0.246 | 0.0176 | 0.1929 |
BMI | IQGAP2 | 5 | rs10036913, rs7722711, rs2431352, rs2910819, rs2455230, rs2431363 | 0.24 | 0.109 | 0.0281 | 0.25 | 0.109 | 0.0238 | 0.3301 |
BMI | MRPS27 | 5 | rs17375461, rs10942927 | −0.44 | 0.193 | 0.0217 | −0.43 | 0.194 | 0.0279 | 0.6049 |
BMI | THBS4 | 5 | rs1866389 | 0.84 | 0.391 | 0.0320 | 0.92 | 0.393 | 0.0195 | 0.2632 |
SBP | ENPP1 | 6 | rs9483347, rs1804025 | 2.10 | 0.915 | 0.0220 | 2.01 | 0.938 | 0.0324 | 0.0310 |
SBP | GPR1266 | 6 | rs11155242 | 2.18 | 0.959 | 0.0234 | 2.15 | 0.959 | 0.0252 | 0.0025 |
SBP | L3MBTL3 | 6 | rs9388768, rs7451021 | 1.23 | 0.522 | 0.0185 | 1.55 | 0.563 | 0.0058 | 0.0481 |
SBP | NOX3 | 6 | rs12195525 | −2.82 | 1.242 | 0.0233 | −2.82 | 1.242 | 0.0233 | 0.4296 |
SBP | RSPO3 | 6 | rs1892172 | 1.58 | 0.809 | 0.0507 | 1.69 | 0.813 | 0.0380 | 0.0165 |
DBP | C6orf184 | 6 | rs9400272, rs6927569 | −1.35 | 0.443 | 0.0023 | −1.37 | 0.451 | 0.0024 | 0.0626 |
DBP | ENPP1 | 6 | rs9483347, rs1804025 | 1.27 | 0.507 | 0.0122 | 1.28 | 0.520 | 0.0135 | 0.0786 |
DBP | L3MBTL3 | 6 | rs9388768, rs7451021 | 0.68 | 0.290 | 0.0192 | 0.82 | 0.313 | 0.0091 | 0.1246 |
DBP | TXLNB | 6 | rs17068451, rs9321712 | 0.75 | 0.317 | 0.0186 | 0.73 | 0.325 | 0.0255 | 0.0112 |
SBP | DOPEY2 | 21 | rs3827183 | 2.97 | 1.248 | 0.0173 | 3.10 | 1.252 | 0.0134 | 0.3174 |
DBP | DOPEY2 | 21 | rs3827183 | 1.40 | 0.691 | 0.0437 | 1.39 | 0.694 | 0.0454 | 0.2382 |
HTN | C6orf211 | 6 | rs9397054 | −0.20 | 0.102 | 0.0484 | −0.20 | 0.103 | 0.0525 | 0.2965 |
HTN | ENPP1 | 6 | rs9483347, rs1804025 | 0.23 | 0.091 | 0.0105 | 0.22 | 0.093 | 0.0162 | 0.0138 |
HTN | L3MBTL3 | 6 | rs9388768, rs7451021 | 0.11 | 0.051 | 0.0358 | 0.14 | 0.055 | 0.0126 | 0.0368 |
HTN | CXADR | 21 | rs437470 | 0.20 | 0.082 | 0.0166 | 0.19 | 0.083 | 0.0227 | 0.1348 |
HDL-C | LOC137886 | 8 | rs13277646 | −1.99 | 0.796 | 0.0125 | −1.98 | 0.799 | 0.0132 | 0.6924 |