Fig. 1.

Lack of Ctip2 is associated with impaired proliferation and delayed onset of differentiation during early stages of epidermal development. (A) Immunofluorescence staining of embryonic skin sections from wild-type (WT) and Ctip2 null (KO) mice with an anti-Ctip2 antibody. (B) Hematoxylin/Eosin-stained sections of dorsal skin collected from WT and KO embryos on the indicated embryonic days. (C–E) Immunofluorescence staining of embryonic skin sections from WT and KO mice with anti-Ki67 (C), anti-K10 (D) and anti-FLG (E) antibodies. The results are representative of at least three independent studies. Abbreviations: D, dermis; E, epidermis. Scale bar: 20 µm.