Table 3.

Genes selected for validation experiments

Expression	No.	Gene symbol	Protein function
Down-regulated in patients of group ha	1	CDKN2C	Cyclin-dependent kinase 4 inhibitor C; member of the INK4 family of cyclin-dependent kinase inhibitors; interacts with CDK4 or CDK6; prevents the activation of the CDK kinases; functions as a cell growth regulator; controls cell-cycle G1 progression
	2	RNF26	Contains a C3HC5 type of RING finger involved in protein-DNA and protein-protein interactions
	3	UQCRH	Mitochondrial Hinge protein
Up-regulated in patients of group hb	4	LRDD	Contains a leucine-rich repeat and a death domain; interacts with Fas and MAPK activating death domain-containing protein MADD; functions as an adaptor protein in signaling processes
	5	HLA-DRB4	HLA-DRB4 belongs to the HLA class II beta-chain paralogs
	6	ADCK2	Uncharacterized aarF domain-containing protein kinase 2
	7	C18orf8	Uncharacterized protein C18orf8 of 657 aa
	8	HIAT1	Putative tetracycline transporter-like protein
Down-regulated in patients of group hb	9	GIMAP1	Belongs to the GTP-binding immuno-associated nucleotide subfamily of nucleotide-binding proteins; is involved in the differentiation of Th cells; is critical for the development of mature B and T lymphocytes
	10	DCAKD	Dephospho-CoA kinase domain-containing protein
	11	FKBP5	Member of the immunophilin protein family; plays a role in immunoregulation and basic cellular processes
	12	GTPBP2	GTP-binding protein member of superfamily capable of binding GTP or GDP
	13	FLJ20366	Syntabulin is a microtubule-associated protein implicated in syntaxin transport
Down-regulated in patients of group hc	14	ETV3	Transcriptional repressor; contributes to growth arrest during terminal macrophage differentiation by repressing target genes
	15	KIF5C	Microtubule-associated force-producing protein; may play a role in organelle transport
	16	RPS27	Ribosomal protein
	17	PDE4B	Involved in many signal transduction pathways; may play an important role in platelet aggregation, hormone secretion, and immune cell activation
	18	DOCK4	Membrane-associated cytoplasmic protein; functions as a guanine nucleotide exchange factor; is involved in the regulation of adherens junctions between cells
	19	RFX7	Ribosomal protein that is a component of the 40S subunit
	20	KIAA1128	Hypothetical protein of 588 aa
Up-regulated in patients of group ha	21	MTHFD1L	Involved in the synthesis of tetrahydrofolate in the mitochondrion