Figure 1.

Bolus injections of increasing doses of (A) acetylcholine and (B) sodium nitroprusside during vasoconstrictions caused by methoxamine in isolated perfused kidneys from WKY, SHR and SHR treated with L-NAME (SHR L-NAME). The results are shown as % dilatation of the increase in perfusion pressure induced by methoxamine, and values are expressed as means ± SEM. (n= 9–10). *P < 0.05, significantly different from the WKY group; $P < 0.05, significant difference between the SHR and L-NAME-treated SHR groups; two-way anova, followed by a Bonferroni post hoc test, 15 and 12 multiple comparisons for acetylcholine and sodium nitroprusside experiments, respectively.