Effects of TRAM-34 (0.5, 1 and 5 µM) on the dilatation due to NS 309 (10 nmol) in isolated perfused kidneys from WKY, SHR and L-NAME-treated SHR (n= 3–7). The experiments were performed in the presence of indomethacin plus L-NA. The results are shown as % dilatation of the increase in perfusion pressure induced by methoxamine, and values are expressed as mean ± SEM. *P < 0.05, AUC significantly different from control; one-way anova followed by a Bonferroni post hoc test, 2–3 and 1 multiple comparisons for TRAM-34 and apamin experiments respectively.