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. 2012 Oct;167(4):854–867. doi: 10.1111/j.1476-5381.2012.02062.x

Table 1.

Physiological and biochemical parameters in normotensive WKY, and SHR with or without treatment with L-NAME

WKY (untreated) SHR (untreated) SHR (L-NAME)
SBP (mmHg) 123 ± 5 (11) 212 ± 10 (21)* 246 ± 6 (22)*$
Heart rate (beats·min−1) 387 ± 9 (11) 380 ± 10 (21) 383 ± 8 (22)
Body weight (g) 391 ± 9 (30) 333 ± 7 (33)* 282 ± 8 (43)*$
Kidney weight (g) 1.46 ± 0.03 (30) 1.32 ± 0.02 (33)* 1.10 ± 0.01 (43)*$
Kidney/body weight (103) 3.63 ± 0.13 (30) 4.03 ± 0.09 (33) 4.16 ± 0.16 (43)*
Micro-albuminuria (mg·24 h−1) <0.01 (9) 0.09 ± 0.01 (12)* 2.7 ± 0.68 (13)*$
Urinary proteins (mg·24 h−1) 19.6 ± 2.6 (15) 11.7 ± 0.8 (15)* 91.1 ± 7.8 (13)*$
Creatinine (mL·min−1·kg−1) 0.61 ± 0.05 (8) 0.38 ± 0.02 (11)* 0.17 ± 0.02 (10)*$
HbNO (arbitrary units) 2171 ± 365 (6) 1582 ± 255 (6) 399 ± 75 (7)*$
Nitrite/nitrate (µmol·24 h−1) 4.02 ± 0.81 (10) 1.38 ± 0.22 (14)* 0.66 ± 0.18 (17)*

Values are shown as mean ± SEM with the number of animal from which kidneys were taken, shown in brackets.

*

P < 0.05 significantly different from WKY,

$

P < 0.05, significantly different from untreated SHR; one-way anova, followed by a Bonferroni post hoc test, three multiple comparisons.

SBP, systolic blood pressure; HbNO, iron nitroxyl-haemoglobin.