Table 1.
Physiological and biochemical parameters in normotensive WKY, and SHR with or without treatment with L-NAME
| WKY (untreated) | SHR (untreated) | SHR (L-NAME) | |
|---|---|---|---|
| SBP (mmHg) | 123 ± 5 (11) | 212 ± 10 (21)* | 246 ± 6 (22)*$ |
| Heart rate (beats·min−1) | 387 ± 9 (11) | 380 ± 10 (21) | 383 ± 8 (22) |
| Body weight (g) | 391 ± 9 (30) | 333 ± 7 (33)* | 282 ± 8 (43)*$ |
| Kidney weight (g) | 1.46 ± 0.03 (30) | 1.32 ± 0.02 (33)* | 1.10 ± 0.01 (43)*$ |
| Kidney/body weight (103) | 3.63 ± 0.13 (30) | 4.03 ± 0.09 (33) | 4.16 ± 0.16 (43)* |
| Micro-albuminuria (mg·24 h−1) | <0.01 (9) | 0.09 ± 0.01 (12)* | 2.7 ± 0.68 (13)*$ |
| Urinary proteins (mg·24 h−1) | 19.6 ± 2.6 (15) | 11.7 ± 0.8 (15)* | 91.1 ± 7.8 (13)*$ |
| Creatinine (mL·min−1·kg−1) | 0.61 ± 0.05 (8) | 0.38 ± 0.02 (11)* | 0.17 ± 0.02 (10)*$ |
| HbNO (arbitrary units) | 2171 ± 365 (6) | 1582 ± 255 (6) | 399 ± 75 (7)*$ |
| Nitrite/nitrate (µmol·24 h−1) | 4.02 ± 0.81 (10) | 1.38 ± 0.22 (14)* | 0.66 ± 0.18 (17)* |
Values are shown as mean ± SEM with the number of animal from which kidneys were taken, shown in brackets.
*
P < 0.05 significantly different from WKY,
$
P < 0.05, significantly different from untreated SHR; one-way anova, followed by a Bonferroni post hoc test, three multiple comparisons.
SBP, systolic blood pressure; HbNO, iron nitroxyl-haemoglobin.