Table 2.
Maximal decreases in perfusion pressure caused by sodium nitroprusside (SNP: 10 nmol) and forskolin (6 nmol) in kidneys from WKY, SHR and L-NAME-treated SHR (in the presence of indomethacin and L-NA). Effects of the potassium channel blockers: TRAM-34, apamin and charybdotoxin
| WKY (untreated) | SHR (untreated) | SHR (L-NAME) | ||
|---|---|---|---|---|
| Control | SNP | 60.3 ± 5.4 (5) | 51.0 ± 3.7 (6) | 64.6 ± 4.4 (14) |
| Forskolin | 62.1 ± 6.9 (6) | 57.3 ± 3.2 (7) | 67.0 ± 4.6 (14) | |
| TRAM-34 (0.5 µmol·L−1) | SNP | – | – | 53.2 ± 5.7 (5) |
| Forskolin | 56.3 ± 4.7 (5) | |||
| TRAM-34 (1 µmol·L−1) | SNP | 64.9 ± 5.3 (4) | 42.9 ± 1.5 (3) | 58.6 ± 6.3 (5) |
| Forskolin | 45.3 ± 6.4 (5) | 49.2 ± 5.2 (3) | 58.9 ± 7.0 (5) | |
| TRAM-34 (5 µmol·L−1) | SNP | 66.8 ± 4.6 (5) | 58.4 ± 4.7 (5) | 46.3 ± 5.3 (5) |
| Forskolin | 65.9 ± 7.7 (6) | 55.3 ± 6.7 (5) | 54.0 ± 2.9 (5) | |
| Apamin (0.5 µmol·L−1) | SNP | 46.6 ± 9.1 (3) | 48.4 ± 4.3 (3) | 52.1 ± 6.8 (4) |
| Forskolin | 55.5 ± 6.9 (3) | 59.4 ± 3.8 (3) | 52.4 ± 4.5 (6) | |
| Apamin (0.5 µmol·L−1) + TRAM-34 (5 µmol·L−1) | SNP | – | – | 43.4 ± 7.8 (5) |
| Forskolin | 71.8 ± 9.4 (5) | |||
| Charybdotoxin (10 nmol·L−1) | SNP | – | – | 65.5 ± 9.8 (3) |
| Forskolin | 68.2 ± 9.8 (3) |
Values are expressed in mmHg and shown as mean ± SEM with the number of animal from which kidneys were taken, shown in brackets.