Table 3.

Effects of TRAM-34 and apamin on NS-309 (10 nmol)-induced vasodilatation (in the presence of indomethacin + L-NA)

	WKY (untreated)	SHR (untreated)	SHR (L-NAME)
Control	40.9 ± 7.6 (5)	65.0 ± 7.5 (7)	161.2 ± 14.7 (7)
TRAM-34 (0.5 µmol·L−1)			96.4 ± 15.4 (5)*
TRAM-34 (1 µmol·L−1)	43.8 ± 13.8 (5)	41.7 ± 8.5 (3)	48.6 ± 10.9 (3)*
TRAM-34 (5 µmol·L−1)	48.1 ± 11.9 (5)	18.4 ± 5.2 (5)*	38.6 ± 6.1 (3)*
Apamin (0.5 µmol·L−1)	24.3 ± 11.4 (2)	67.6 ± 5.6 (3)	164.4 ± 29.1 (6)
Apamin + TRAM-34 (5 µmol·L−1)			42.5 ± 8.3 (6)*

Values are expressed as AUC (arbitrary units) and are shown as mean ± SEM with the number of animal from which kidneys were taken in brackets.

^*P < 0.05, significantly different from control; one-way anova.