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. 2012 Dec 27;41(4):2683–2688. doi: 10.1093/nar/gks1304

Figure 3.

Figure 3.

Determination of the G-quadruplex folding topology for the s2 and s4 sequences in K+ solution. (a and c) The imino-H8 proton region of NOESY spectra (mixing time, 200 ms) of s2 and s4, respectively at 25°C. The characteristic guanine imino-H8 cross-peaks for G-tetrads (colored red, yellow and blue, respectively) are framed and labeled with the imino proton assignment in the first position and that of the H8 proton in the second position. (b and d) The H8/6-H1′ proton region of NOESY spectra (mixing time, 300 ms) of s2 and s4, respectively at 25°C. The assignments and H8/6-H1′ NOE sequential connectivities are shown.