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. 2013 Jan 8;41(4):2121–2137. doi: 10.1093/nar/gks1457

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Network analysis of Alu-containing genes responsive to viral recovery from iPOP experimental data set. Alu-containing genes with anti-correlated sense versus antisense levels (poly-A⁺ RNA-seq and small RNA-seq, respectively) during viral recovery were used as query in the BioGRID database for experimentally verified protein–protein interactions. The network analysis reveals that majority of such genes (shown in grey) interact either directly or via an intermediary (shown in white) to ubiquitin conjugating enzyme (UBC). Ubiquitin-proteasomal system is known to be an integral component of host defence against viral infections.