Table II.

Classification of the Antiprion Mechanisms

Class	Mechanism	Biacore	NMR
I	Specific conformational stabilization of PrPC	Specific binding	Specific binding
II	Nonspecific stabilization of PrPC	Nonspecific binding	Nonspecific binding
III	Aggregation and precipitation to reduce PrPC population	Nonspecific binding	Not detectable
IV	Interaction with molecules other than PrPC	No binding	No interaction