Table 2.
Serum folate levels according to genotype and case–control status
| Cases adjusted serum folate nmol/L mean ± SDa (median) |
PTrend | Controls adjusted serum folate nmol/L mean ± SDa (median) |
PTrend | |
|---|---|---|---|---|
| MTHFR C677T | ||||
| CC | 12.8 ± 0.4 (10.7) | 0.155 | 9.8 ± 0.4 (9.1) | 0.091 |
| CT | 11.8 ± 0.7 (10.1) | 9.2 ± 0.7 (9.1) | ||
| TT | – | 7.0 ± 1.7 (6.1) | ||
| MTHFR A1298C | ||||
| AA | 12.4 ± 0.4 (12.4) | 0.523 | 9.6 ± 0.4 (8.9) | 0.898 |
| AC | 13.0 ± 0.7 (13.8) | 9.5 ± 0.7 (9.8) | ||
| CC | 12.8 ± 1.4 (11.6) | 9.6 ± 1.72 (9.0) | ||
| MTRR A66G | ||||
| AA | 12.1 ± 0.4 (12.0) | 0.511 | 9.5 ± 0.4 (9.3) | 0.944 |
| AG | 13.4 ± 0.5 (13.1) | 9.5 ± 0.6 (8.6) | ||
| GG | 12.1 ± 1.1 (12.2) | 9.6 ± 1.3 (8.1) | ||
| MTR A2756G | ||||
| AA | 12.4 ± 0.5 (11.9) | 0.693 | 9.6 ± 0.5 (8.7) | 0.525 |
| AG | 13.0 ± 0.5 (13.0) | 9.2 ± 0.5 (9.0) | ||
| GG | 11.8 ± 0.9 (11.3) | 10.6 ± 0.9 (10.7) | ||
| MTHFR C677T/A1298C | ||||
| CC + AA | 12.8 ± 0.4 (12.7) | 0.295 | 10.0 ± 0.5 (9.0) | 0.228 |
| CC + (AC + CC) | 12.8 ± 0.6 (12.6) | 9.3 ± 0.7 (9.3) | ||
| (CT + TT) + AA | 11.1 ± 0.8 (10.5) | 8.6 ± 0.7 (8.4) | ||
| (CT + TT) + (AC + CC) | 13.7 ± 1.4 (14.2) | 11.0 ± 1.9 (12.4) | ||
aSerum folate means adjusted for vitamin use