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. 2012 Sep 25;8(2):199–207. doi: 10.1007/s12263-012-0321-7

Table 3.

Odds ratios (OR) and 95 % CI for association of serum folate concentrations with prostate cancera

Tertiles of serum folate ptrend Folate per 10 nmol/L OR (95 % CI)
1
OR
2
OR (95 % CI)
3
OR (95 % CI)
Serum folate, nmol/L 2.9–7.3 7.4–10.9 11.0–24.0
Total prostate cancera
 Cases/controls 32/77 53/80 133/79 218/236
 Age adjusted 1.00 (ref.) 2.06 (1.15–3.67) 4.83 (2.82–8.25) 0.0001 4.81 (2.89–7.98)
 Multivariableb 1.00 (ref.) 2.82 (1.44–5.53) 5.82 (3.12–10.88) 0.0001 4.41 (2.52–7.72)
 Low-grade cancerc
 Cases/controls 15/77 26/80 54/79 95/236
 Age adjusted 1.00 (ref.) 2.07 (0.99–4.32) 4.02 (2.04–7.92) 0.0001 4..07 (2.23–7.46)
 Multivariableb 1.00 (ref.) 2.83 (1.18–6.74) 5.26 (2.34–1.84) 0.0001 3.98 (2.05–7.76)
High-grade cancerd
 Cases/controls 15/77 26/80 75/79 116/236
 Age adjusted 1.00 (ref.) 2.35 (1.11–4.98) 5.79 (2.95–11.36) 0.0001 4.81 (2.65–8.70)
 Multivariableb 1.00 (ref) 3.05 (1.27–7.30) 6.78 (3.06–15.03) 0.0001 4.51 (2.31–8.82)

a7 cases—Gleason scores unknown

bModels adjusted for age and BMI and total energy intake as continuous, education (primary or less, secondary or higher), family history of prostate cancer (no/yes), vitamin use (no/yes), alcohol intake (non-drinker, <6.4, >6.4 g/day), and smoking (non-smoker, ex-smoker, current smoker)

cLow-grade cancer indicates Gleason score of <7

dHigh-grade cancer indicates Gleason score of ≥7