Table 4.
Odds ratios (OR) and 95 %CI for association of dietary folate concentrations with prostate cancera
| Tertiles of dietary folate | ptrend | |||
|---|---|---|---|---|
| 1 OR |
2 OR |
3 OR (95 % CI) |
||
| Folate intake (μg/d) | 172–634 | 635–926 | 927–1121 | |
| Total prostate cancera | ||||
| Cases/controls | 69/75 | 79/76 | 61/76 | |
| Multivariableb | 1.00 (ref.) | 2.24 (0.95–5.55) | 2.49 (1.16–5.19) | 0.006 |
| Low-grade cancerc | ||||
| Cases/controls | 34/75 | 38/80 | 29/79 | |
| Multivariableb | 1.00 (ref.) | 3.27 (0.99–10.86) | 2.58 (1.05–6.34) | 0.004 |
| High-grade cancerd | ||||
| Cases/controls | 33/75 | 40/80 | 28/79 | |
| Multivariableb | 1.00 (ref) | 1.38 (0.49–3.62) | 1.92 (1.01–5.47) | 0.019 |
a7 cases—Gleason scores unknown
bModels adjusted for age and BMI and total energy intake as continuous, education (primary or less, secondary or higher), family history of prostate cancer (no/yes), vitamin use (no/yes), alcohol intake (non-drinker, < 6.4, > 6.4 g/day), and smoking (non-smoker, ex-smoker, current smoker)
cLow-grade cancer indicates Gleason score of <7
dHigh-grade cancer indicates Gleason score of >7