Table 1.

Functional annotation analysis (DAVID) for up- and downregulated genes in the comparison of Control sample to directly frozen human mucosa (DF)

Category	Annotation term	Significance (FDR)	Molecules
Upregulated genes
Biological processes (top ten regulated terms)	Apoptosis	1.53E−07	30
	Death	1.54E−07	31
	Cell death	1.54E−07	31
	Programmed cell death	1.86E−07	30
	Biological regulation	3.21E−07	94
	Cell development	3.71E−06	36
	Developmental process	4.20E−06	66
	Cell differentiation	6.70E−06	45
	Cellular developmental process	6.75E−06	45
	Negative regulation of biological process	1.02E−05	34
Cellular components	Intracellular part	3.29E−02	130
Molecular functions	Protein binding	1.27E−07	113
	Binding	1.18E−02	153
KEGG pathway	Complement and coagulation cascades	4.83E−03	7
Downregulated genes
Cellular components	Organelle membrane	2.36E−04	14
	Mitochondrial inner membrane	9.46E−03	6
	Organelle inner membrane	1.28E−02	6
	Cytoplasmic part	2.34E−02	19
	Mitochondrial part	2.48E−02	7
	Mitochondrial membrane	2.84E−02	6
	Mitochondrion	3.13E−02	9
	Organelle envelope	3.45E−02	7
	Mitochondrial envelope	3.50E−02	6
	Envelope	3.52E−02	7
	Integral to organelle membrane	3.97E−02	4
	Membrane	4.01E−02	28