Table 3.
Functional annotations analysis corresponding to up- and downregulated genes in Inflamed compared to Control and to downregulated genes in iBL23, iLP and iLP(A−) compared to Inflamed sample (The analysis is based on the default parameters in D.A.V.I.D. and uses FDR correction for multiple testing)
| Inflamed versus CTRL | iLP versus Inflamed | iLP(A−) versus Inflamed | iBL23 versus Inflamed | ||
|---|---|---|---|---|---|
| Category | ↑ Regulated genes | ↓ Regulated genes | ↓ Regulated genes | ↓ Regulated genes | ↓ Regulated genes |
| Biological Processes | Immune response | Response to wounding | Immune response | Immune response | Immune response |
| Immune system process | Wound healing | Taxis | Immune system process | Immune system process | |
| Positive regulation of immune system process | Regulation of localization | Chemotaxis | Response to external stimulus | Regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | |
| Regulation of lymphocyte proliferation | Regulation of transport | Response to external stimulus | Response to wounding | Regulation of adaptive immune response | |
| Regulation of leukocyte proliferation | Response to external stimulus | Immune system process | Response to stimulus | Response to external stimulus | |
| Cellular components | ns | ns | Extracellular space | Extracellular space | Extracellular space |
| Extracellular region part | Extracellular region part | Extracellular region part | |||
| Extracellular region | Extracellular region | ||||
| Molecular functions | Cytokine activity | Heparin binding | Cytokine activity | Cytokine activity | Cytokine activity |
| Glycosaminoglycan binding | Chemokine activity | Receptor binding | Receptor binding | ||
| Pattern binding | Chemokine receptor binding | Chemokine activity | Chemokine activity | ||
| Polysaccharide binding | G-protein-coupled receptor binding | Chemokine receptor binding | G-protein-coupled receptor binding | ||
| Receptor binding | G-protein-coupled receptor binding | Chemokine receptor binding | |||
| KEGG pathways | Cytokine–cytokine receptor interaction | ns | Cytokine–cytokine receptor interaction | Cytokine–cytokine receptor interaction | Cytokine–cytokine receptor interaction |
| Jak-STAT signaling pathway | Jak-STAT signaling pathway | ||||
KEGG Kyoto encyclopedia of genes and genomes; ns none significant