Pharmacokineticsof GSK2190915. Mean plasma concentration vs. time profiles for GSK2190915 in healthy Western European subjects on (A) day 1 after single dose administration of 50 mg, (), 150 mg (), 300 mg (), 600 mg () or 1000 () mg. Mean plasma concentration vs. time profiles for GSK2190915 in healthy Western European subjects on (B) day 1 or (C) day 11 following multiple dose administration of 10 mg (), 50 mg, (), 150 mg () or 450 mg ().