Table 3.
Japanese GSK2190915 PK summary. Geometric mean (%CV) of AUC(0,24 h), AUC(0,∞), AUC(0,∞)/D, Cmax, Cmax/D, CL/F, Vz/F and t1/2 and median tmax (minimum – maximum)
| Dose | AUC(0,24 h) (ng ml−1 h) | AUC(0,∞) (ng ml−1 h) | AUC(0,∞)/D (ng ml−1 h) | Cmax (ng ml−1) | Cmax/D (ng ml−1) | tmax (h) | t1/2 (h) | CL/F (l h−1) | Vz/F (l) |
|---|---|---|---|---|---|---|---|---|---|
| Single (n = 9, except for 200 mg dose group where n = 8) | |||||||||
| 10 mg | 825 (16) | 1752 (31) | 175 | 45 (21) | 4.5 | 6.00 (2.00–24.00) | 19.7 (17) | 5.71 (31) | 162 (27) |
| 50 mg | 5155 (45) | 10256 (64) | 205 | 372 (49) | 7.4 | 6.00 (2.00–12.00) | 23.0 (23) | 4.88 (65) | 162 (42) |
| 150 mg | 16956 (49) | 31973 (38) | 213 | 1462 (53) | 9.7 | 4.00 (2.00–6.00) | 18.8 (24) | 4.69 (38) | 127 (44) |
| 200 mg | 26271 (39) | 41021 (39) | 205 | 2128 (54) | 10.6 | 4.00 (2.00–6.00) | 16.0 (19) | 4.88 (39) | 113 (35) |
AUC = Area under the curve; Cmax = maximum concentration; CL/F = apparent clearance; D = Dose;; t1/2 = half‐life; tmax = time to maximum plasma concentration; Vz/F = apparent volume of distribution.