Table 3.
Fully adjusted models for any radiographic ICH and symptomatic ICH
| Characteristics | Model 1: Any ICH | Model 2: slCH | |||
|---|---|---|---|---|---|
| aOR | (95% Cl) | Category for Model 2 | aOR | (95% Cl) | |
| Pre-existing antiplatelet use | 1.13 | (0.76–1.68) | 1.26 | (0.72–2.19) | |
| Post tPA treatment protocol deviations | 1.00 | (0.65–1.52) | 1.57 | (0.90–2.75) | |
| History of tobacco use | 0.70 | (0.40–1.24) | 0.32 | (0.11–0.94) | |
| Systolic blood pressure (10 mmHg increase) | 1.07 | (0.97–1.17) | 1.09 | (0.96–1.25) | |
| Onset to treatment time in minutes | 1.00 | (0.995–1.004) | 0.997 | (0.99–1.004) | |
|
| |||||
| Baseline NIHSS | |||||
| 1 – 6 | 0.29 | (0.15–0.55) | 1–11 | 0.53 | (0.30–0.95) |
| 7 – 11 | 0.33 | (0.19–0.55) | |||
| 12 – 15 | 0.72 | (0.44–1.17) | 12+ | ref | |
| 16+ | ref | ||||
|
| |||||
| Age in Years | |||||
| 20 – 57 | 0.41 | (0.20–0.83) | 20–70 | 0.52 | (0.27–1.001) |
| 58 – 70 | 0.80 | (0.47–1.37) | |||
| 71 – 70 | 0.83 | (0.51–1.37) | 71+ | ref | |
| 81+ | ref | ||||
|
| |||||
| Baseline Blood Glucose (mg/DL) | |||||
| 59 – 101 | 0.50 | (0.28–0.91) | 59–118 | 1.00 | (0.58–1.73) |
| 102 – 118 | 0.69 | (0.41–1.16) | |||
| 119 – 144 | 0.83 | (0.50–1.39) | 119+ | ref | |
| 145+ | ref | ||||
Final models evaluating the relationship between intracranial hemorrhage (ICH) and antiplatelet use. sICH = symptomatic ICH; aOR = adjusted odds ratio; NIHSS = National Institutes of Health Stroke Scale; TIA = transient ischemic attack.
Age, severity, and glucose were divided into quartiles (Model 1) or dichotomized (Model 2) to allow for non-linear effects. Model 1 fit was satisfactory (c-statistic 0.704, Hosmer and Lemeshow Goodness of Fit Test failed to reject hypothesis of lack of fit p = 0.76) as was the fit of Model 2 (c-statistic 0.719, Hosmer and Lemeshow Goodness of Fit Test p = 0.14).