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. Author manuscript; available in PMC: 2013 Feb 19.
Published in final edited form as: Neuroscience. 2011 Sep 17;197:72–79. doi: 10.1016/j.neuroscience.2011.09.027

Figure 2. Ketamine-xylazine induced delta-oscillations correlate with brain regional ATP-concentrations.

Figure 2

(A) Coronal slices with red indicated sampled regions in frontal cortex (FC), basal forebrain (BF), cingulate cortex (CCX) and hippocampus (HIPP) (Paxinos and Watson, 2005). (B) Percent increase in ATP concentrations in 4 brain regions after KX. ATP concentrations increased significantly (ANOVA H=42.162, df (7), P=0.001) in FC, BF, CCX and HIPP after KX treatment when compared to saline treated controls. (C) Correlation between ATP concentrations in μmol/g tissue for 4 brain regions and cortical EEG delta activity. Note the strong positive correlations between ATP levels and EEG delta activity. Closed circles = values after KX. Open circles = control values (saline treatment).