Figure 12. .

Detection of apoptotic cells by TUNEL staining from the treated and control eyes harvested 2 weeks following intravitreal injection. (A) A section from a study control eye showing normal retinal structures and no apoptotic cells. (B) A section from a cov-OPS:DNR-injected eye, showing normal retinal structures similar to those in the section in (A) from its contralateral control eye. No apoptotic activity was detected. (C) Negative control section. (D) Positive control section, showing brownish positive staining of cells in all three layers of the retina. The sections were counterstained with hematoxylin. All four images are at ×62.5 magnification.