FIGURE 11.

The rRNA promoter contains a putative quadruplex forming G-rich sequences and enriched by G/C sequences. The sequence of human rRNA promoter between positions 42801 and 27 (numbering corresponds to that of the complete human rDNA repeat, accession number U13369, GenBank) was analyzed by QGRC Mapper software (53) and positions of quadruplex forming sequences (G1–G4) and G-scores are indicated above schematic representation of the promoter. The same sequence was analyzed by Vector NTI (Invitrogen) and positions of GpC, GpG, CpG, and CpG motifs are shown below schematic representation of the promoter. UCE, upstream binding element.