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Influence of slow and fast seeds on the kinetics of PrP fibril formation. A and B, 22 μm PrPa (A) or PrPb (B) was incubated in the absence (A, open triangles) or the presence of 0.5% (v/v) slow (filled circles) or fast (filled squares) seeds. The original kinetics of the reactions that produced the S and F seeds are shown for comparison, as a dotted line (F) and dashed line (S). n = 3 for unseeded reactions; n = 2 for seeded reactions. Error bars indicate ± S.E.
