Sequence alignment of AgTG3(22–748) with transglutaminases of known structure: FXIII, hTG2, hTG3, and P. major TG. Secondary structure elements colored and labeled by domain. Identical residues are shaded gray, similar residues are boxed in gray. Catalytic residues are shaded yellow, Ca2+-binding residues (based upon hTG3) are shaded pink. FXIII residues at the dimer interface are shaded green. Numbering corresponds to AgTG3 full-length sequence. Figure was generated with ESPRIPT (42).