FIGURE 10.

Current model of apoA-IV structure and possible implications for its various functions. ApoA-IV exists predominantly as a monomer and dimer, and both have low lipid affinity. Low lipid affinity is regulated through interactions with the N and C termini, which also interact with the main bundle. Disrupting these interactions increases the lipid affinity of apoA-IV. It is possible that different functions of apoA-IV are associated with a lipid- or lipid-free state, which is mediated through a clasp mechanism.