Table 3.
Site-Specific Cancer and SIR in Schizophrenia Patients by Age Group at Diagnosis
| All | Age >50 y | Age <50 y | ||||
| Site (ICD9 code) | Number of Cancers Observed | SIR (95% CI) | Number of Cancers Observed | SIR (95% CI) | Number of Cancers Observed | SIR (95% CI) |
| Overall cancer (140–208) | ||||||
| Oral cavity | 128 | 1.13 (0.87–1.45) | 30 | 0.77 (0.48–1.24) | 98 | 1.31 (0.97–1.77) |
| Mouth and tongue (141, 144–145) | 53 | 0.94 (0.53–1.66) | 11 | 0.59 (0.28–1.24) | 42 | 1.12 (0.72–1.74) |
| Pharynx (146–147) | 47 | 1.30 (0.82–2.07) | 8 | 0.86 (0.37–2.01) | 33 | 1.47 (0.86–2.52) |
| Digestive | ||||||
| All (150–159) | 340 | 1.02 (0.88–1.19) | 159 | 0.73 (0.60–0.90)* | 181 | 1.57 (1.24–1.98) ** |
| Stomach (151) | 48 | 1.14 (0.75–1.72) | 24 | 0.86 (0.50–1.48) | 24 | 1.70 (0.88–3.27) |
| Colorectal (153–154) | 108 | 0.98 (0.75–1.28) | 54 | 0.72 (0.51–1.03) | 54 | 1.53 (1.00–2.34)* |
| Liver (155) | 124 | 0.92 (0.72–1.18) | 56 | 0.66 (0.47–0.93)* | 68 | 1.36 (0.94–1.96) |
| Respiratory | ||||||
| All (160–165) | 88 | 0.91 (0.68–1.22) | 53 | 0.75 (0.53–1.07) | 35 | 1.36 (0.82–2.27) |
| Lung (162) | 78 | 0.93 (0.69–1.27) | 51 | 0.80 (0.55–1.16) | 27 | 1.36 (0.76–2.43) |
| Bone, skin, and breast | ||||||
| All (170–175) | 244 | 1.50 (1.23–1.83) ** | 100 | 1.46 (1.07–1.98)* | 144 | 1.53 (1.18–1.99) ** |
| Breast (174), female only | 215 | 1.68 (1.35–2.09) ** | 88 | 1.75 (1.24–2.47)* | 127 | 1.64 (1.24–2.17) ** |
| Genitourinary | ||||||
| All (179–189) | 208 | 1.36 (1.10–1.67)* | 101 | 1.13 (0.85–1.51) | 107 | 1.67 (1.23–2.28) ** |
| Cervix of uterus (180), female only | 74 | 1.41 (0.99–2.02) | 29 | 1.19 (0.69–2.04) | 45 | 1.61 (1.00–2.58)* |
| Body of uterus (182), female only | 39 | 2.15 (1.23–3.75)* | 15 | 1.61 (0.71–3.65) | 24 | 2.71 (1.25–5.86) ** |
| Prostate (185), male only | 10 | 0.64 (0.29–1.42) | 10 | 0.66 (0.30–1.46) | 0 | NA |
| Bladder (188) | 25 | 1.15 (0.65–2.05) | 18 | 1.11 (0.57–2.18) | 7 | 1.27 (0.42–3.89) |
| Kidney (189) | 24 | 1.16 (0.64–2.08) | 15 | 1.02 (0.50–2.10) | 9 | 1.49 (0.53–4.16) |
| Other and unspecified | ||||||
| All (190–199) | 70 | 1.17 (0.83–1.65) | 25 | 1.14 (0.64–2.02) | 45 | 1.19 (0.77–1.83) |
| Brain (191) | 15 | 1.44 (0.65–3.17) | 4 | 1.15 (0.27–4.85) | 11 | 1.58 (0.61–4.09) |
| Thyroid and other endocrine (193–194) | 22 | 0.65 (0.38–1.11) | 4 | 0.45 (0.14–2.48) | 18 | 0.71 (0.39–1.31) |
| Haemopoietic | ||||||
| All (200–208) | 51 | 1.14 (0.76–1.71) | 18 | 0.95 (0.50–1.82) | 33 | 1.28 (0.76–2.14) |
| Lymphoma (200–203) | 26 | 1.00 (0.58–1.71) | 11 | 0.92 (0.41–2.09) | 15 | 1.06 (0.51–2.19) |
| Leukemia (204–208) | 25 | 1.35 (0.74–2.46) | 7 | 1.01 (0.35–2.90) | 18 | 1.54 (0.74–3.23) |
Note: Abbreviation is explained in the first footnote to table 1.
*P value for SIR of cancer <.05; **P value for SIR of cancer <.001.