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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Hypertension. 2012 Dec 10;61(2):417–424. doi: 10.1161/HYPERTENSIONAHA.112.201889

Figure 5.

Figure 5

Immunohistochemical staining for α-SMA (brown) on kidneys sections obtained from vehicle, valsartan, aliskiren, and combination-treated mRen2.Lewis hypertensive rats. Kidneys from vehicle treated mRen2.Lewis rats showed the expected α-SMA expression in the mural cells of the vasculature and occasionally in the peritubular interstitium whereas in the treated groups there was an increase in the expression of α-SMA in the interstitium (peritubular and periglomerular) indicating the activation of myofibroblasts leading to fibrosis. Remarkably, the increase in interstitial expression of α-SMA was more significant in the aliskiren and combined therapy groups. Scale bar: 200 µm.