Table 1.

Effects of treatments on heart and kidney weight

Variable	Vehicle (n=9)	Valsartan (n=10)	Aliskiren (n=10)	Combination (n=10)
WHW/BW (mg/g)	3.85 ± 0.06	3.10 ± 0.03^***	3.25 ± 0.08^***	3.02 ± 0.04^***,^§
WHW/TL (mg/mm)	36.8 ± 0.5	29.0 ± 0.4^***	30.7 ± 0.2^***,^†	28.1 ± 0.4^***,^§§§
LVW/BW (mg/g)	2.74 ± 0.04	2.10 ± 0.03^***	2.16 ± 0.05^***	1.97 ± 0.03^***,^§§§
LVW/TL (mg/mm)	26.2 ± 0.41	19.6 ± 0.24^***	20.4 ± 0.20^***	18.3 ± 0.29^***,^†,^§§§
KW/BW (mg/g)	3.82 ± 0.05	3.95 ± 0.10	4.17 ± 0.12	4.35 ± 0.11^**,^†
KW/TL (mg/mm)	36.5 ± 0.4	36.9 ± 0.9	39.5 ± 1.1	40.5 ± 0.9^*,^†

WHW: whole heart weight, BW: body weight, TL: tibia length, LVW: left ventricular weight, KW: kidney weight. Values are means ± SEM.

: P<0.05 vs vehicle,

^†

: P<0.05 vs valsartan,

^§

: P<0.05 vs aliskiren,

^**

: P<0.01 vs vehicle,

^***

: P<0.001 vs vehicle,

^§§§

: P<0.001 vs aliskiren