Table IV.
Effect of treatment with PYM, HCPT or PYM/HCPT on transplanted tumor growth in nude mice.
| Gross tumor volume (mm3, mean ± SD)
|
|||
|---|---|---|---|
| Groups | Pre-therapy | Post-treatment | Rate of depression tumor growth (%) |
| Blank | 121±34 | 2452±456 | - |
| PYM | 108±23 | 1356±342 | 45±18.2 |
| HCPT | 119±29 | 1456±406 | 41±16.1 |
| PYM/HCPT | 123±22 | 634±145 | 74±14.7 |
The change in the gross tumor volume in each of the four treatment groups between pre-therapy and post-treatment is shown (n=5). No significant differences were observed in any of the groups prior to treatment (P>0.05). Significant differences were observed between pre-therapy and post-treatment (P<0.01) in all groups. Significant differences were observed between the PYM/HCPT, PYM and HCPT groups (P<0.01). HCPT, hydroxycamptothecin; PYM, pingyangmycin.