Table IV.

Multivariate analysis of OS.

Covariate	HR	95% CI	P-value
Weekly arm vs. standard arm	0.634	0.422–0.948	0.0262a
Female vs. male	0.528	0.289–0.947	0.0320a
Never smoked vs. smoker	0.727	0.415–1.255	0.2557b
Age <70 years vs. ≥70 years	1.078	0.714–1.647	0.7245b
PS 0/1/2 vs. 3/4	0.296	0.167–0.550	0.0002a
Non-sq vs. sq	0.957	0.610–1.526	0.8501b
TKI used vs. never used	0.495	0.327–0.744	0.0007a
Stage IIIB vs. IV	0.485	0.301–0.756	0.0011a
Neutropenia
(G3 or G4 vs. G0)	0.372	0.215–0.654	0.0007a
(G1 or G2 vs. G0)	0.825	0.448–1.527	0.5392b
(G3 or G4 vs. G1 or G2)	0.450	0.281–0.728	0.0013a
Anemia
(G3 or G4 vs. G0)	9.527	3.415–29.301	<0.0001a
(G1 or G2 vs. G0)	3.514	1.422–9.775	0.0056a
(G3 or G4 vs. G1 or G2)	2.711	1.641–4.404	0.0001a
Thrombocytopenia
(G3 or G4 vs. G0)	0.870	0.424–1.709	0.6290b
(G1 or G2 vs. G0)	0.785	0.525–1.177	0.2407b
(G3 or G4 vs. G1 or G2)	1.108	0.570–2.047	0.7538b

^aP<0.05.

^bnot significant. OS, overall survival; HR, hazard ratio; CI, confidence interval; PS, performance status; Sq, squamous cell carcinoma; TKI, tyrosine kinase inhibitor; G, grade, ns, not significant.