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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Crit Care Med. 2012 Oct;40(10):2788–2796. doi: 10.1097/CCM.0b013e31825b8ade

Figure 3.

Figure 3

Probability of successful extubation on the day following sedative exposure, adjusted for parent study treatment group age, SOFA score, and mental status on the day of sedative exposure, over plausible ranges of (A) daytime hourly average benzodiazepine dose, (B) daytime average hourly propofol dose, (C) the day-to-night change in hourly average benzodiazepine dose and (D) the day-to-night change in hourly average propofol dose. Gray ribbons represent 95% confidence bounds. All plots adjusted to the median (continuous variables) and mode (categorical variables) of model covariates.

Interpretive examples: For patients in whom the average hourly dose of propofol is 30 mcg/kg/min during the daytime, the probability of a successful extubation on the subsequent day is approximately 0.2 panel B. For patients in whom the average hourly dose of benzodiazepines is increased by 1 mg/hr at night, the probability of a successful extubation on the subsequent day is approximately 0.1 panel C after adjusting for covariates including daytime benzodiazepine dose.