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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Crit Care Med. 2012 Oct;40(10):2788–2796. doi: 10.1097/CCM.0b013e31825b8ade

Figure 4.

Figure 4

Probability of delirium on the day following sedative exposure, adjusted for parent study treatment group, age, SOFA score, and mental status on the day of sedative exposure, over plausible ranges of (A) daytime hourly average benzodiazepine dose, (B) daytime average hourly propofol dose, (C) the day-to-night change in hourly average benzodiazepine dose and (D) the day-to-night change in hourly average propofol dose. Gray ribbons represent 95% confidence bounds. All plots adjusted to the median (continuous variables) and mode (categorical variables) of model covariates.

Interpretive examples: For patients in whom the average hourly dose of benzodiazpines is 2 mg/hr during the daytime and who are assessable for delirium the following day, the probability of experiencing delirium is approximately 1.0 panel A). For patients in whom the average hourly dose of propofol is increased by 10 mcg/kg/min at night, the probability of experiencing delirium on the subsequent day is approximately 0.1 panel D after adjusting for covariates including daytime propofol dose.