Table 1.

Cohort characteristics and outcomes ^~

	All Patients (N = 140)
Age, yrs	66 [55 – 75]
Female gender	70 (50)
APACHE II score on admission	27 [22 – 33]
SOFA score	9.0 [7– 12]
Diagnosis of sepsis on admission, N (%)	60 (43)
Days of mechanical ventilation	5.6 [2.6 – 9.6]
ICU length of stay, days	8.6 [5.4 – 13.9]
Intervention arm in parent trial, N (%)	70 (50)
Study outcomes per patient day
Delirium, N (% of 485 days)*	160 (33)
Coma, N (% of 485 days)*	206 (42)
Successful SBT, N (% of 177 days) ^	73 (41)
Successful extubation, N (% of 196 days) #	39 (20)

^~Data presented as median [interquartile range] or N (%) as appropriate

^*Mental status was assessed on all study days prior to death or discharge

^{^}Success of SBTs was determined on days when an SBT was performed

^#Success of extubation was determined on days when an SBT was performed and/or extubation (planned or self) occurred

Abbreviations: APACHE = Acute Physiologic and Chronic Health Evaluation; SOFA Sequential Organ Failure Assessment score