Table 2.
Variation in sedative dosing during the night*
| Study day | ||||
|---|---|---|---|---|
| Variable | One (N=138)~ |
Two (N=132)~ |
Three (N=120)~ |
Four (N=109)~ |
| Benzodiazepines, N (%) receiving drug | 56 (41) | 51 (39) | 42 (35) | 43 (39) |
| Dose decreased at night, N (%) | 23 (41) | 25 (49) | 21 (50) | 17 (40) |
| Dose unchanged at night, N (%) | 8 (14) | 7 (14) | 7 (17) | 7 (16) |
| Dose increased at night, N (%) | 25 (45) | 19 (37) | 14 (33) | 19 (44) |
| Increase in hourly dose at nighttime, mg/hr^ | 0.4 [0.2, 0.8] | 0.5 [0.1, 0.8] | 0.2 [0.2, 0.5] | 0.2 [0.1, 0.5] |
| Propofol, N (%) receiving drug | 83 (60) | 57 (43) | 39 (33) | 30 (28) |
| Dose decreased at night, N (%) | 46 (55) | 30 (53) | 13 (33) | 21 (70) |
| Dose unchanged at night, N (%) | 5 (6) | 6 (10) | 3 (8) | 0 (0) |
| Dose increased at night, N (%) | 32 (39) | 21 (37) | 23 (59) | 9 (30) |
| Increase in hourly dose at nighttime, mg/kg/min^ | 8 [5, 13] | 4 [3, 11] | 8.5 [5, 19] | 5 [3, 18] |
*
Nighttime period corresponds to 11pm – 7am; all dosing expressed as median [IQR]
~
Cohort totals (N) correspond to number of eligible patients, including those no longer receiving a sedative, with complete sedation data (i.e., data collected before ICU discharge or death)
^
Change in nighttime dose determined only among patients with increase in dose