Table 4.
Test and performance characteristics of claims–based definitions for febrile neutropenia
| Gold standard: | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |
|
|
FN: |
No FN: |
|
FN: |
No FN: |
|
FN: |
No FN: |
|
FN: |
No FN: |
|
FN: |
No FN: |
| |
Claims–Based Definitions: |
FN: |
47 |
7 |
FN: |
55 |
16 |
FN: |
28 |
0 |
FN: |
55 |
23 |
FN: |
71 |
130 |
| |
|
No FN: |
35 |
268 |
No FN: |
27 |
259 |
No FN: |
54 |
275 |
No FN: |
27 |
252 |
No FN: |
11 |
145 |
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Test/Performance Characteristic* |
|
|
Neutropenia, Primary Position |
|
Neutropenia, Any Position |
|
Neutropenia + Fever,Any Position |
|
Neutropenia or Fever, Any Position |
|
Neutropenia, Fever, or Infection, Any Position |
|||||
| Patient Classification, % |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| True–Positive |
|
|
13% (10–17) |
|
15% (11–19) |
|
8% (5–11) |
|
15% (11–19) |
|
20% (16–24) |
|||||
| False–Positive |
|
|
2% (0–3) |
|
4% (2–7) |
|
0% (–––) |
|
6% (4–9) |
|
36% (31–42) |
|||||
| True–Negative |
|
|
75% (70–79) |
|
73% (68–77) |
|
77% (73–81) |
|
71% (66–75) |
|
41% (36–45) |
|||||
| False–Negative |
|
|
10% (7–13) |
|
8% (5–10) |
|
15% (11–18) |
|
8% (5–10) |
|
3% (1–5) |
|||||
| Sensitivity, % |
|
|
57% (46–68) |
|
67% (56–77) |
|
34% (24–45) |
|
67% (56–77) |
|
87% (79–94) |
|||||
| Specificity, % |
|
|
97% (96–99) |
|
94% (91–97) |
|
100% (–––) |
|
92% (88–95) |
|
53% (47–59) |
|||||
| Positive Predictive Value (PPV), % |
|
|
87% (78–95) |
|
77% (68–87) |
|
100% (–––) |
|
71% (61–80) |
|
35% (29–42) |
|||||
| Negative Predictive Value (NPV), % |
|
|
88% (85–92) |
|
91% (87–94) |
|
84% (80–87) |
|
90% (87–94) |
|
93% (89–97) |
|||||
| Accuracy, % |
|
|
88% (85–91) |
|
88% (85–91) |
|
85% (82–89) |
|
86% (82–90) |
|
61% (55–66) |
|||||
| Likelihood ratio positive (LR+) |
|
|
22.5 (12.3–68.5) |
|
11.5 (7.6–20.4) |
|
––– |
|
8.0 (5.6–13.4) |
|
1.8 (1.6–2.1) |
|||||
| Likelihood ratio negative (LR–) | 0.4 (0.3–0.6) | 0.3 (0.2–0.5) | 0.7 (0.6–0.8) | 0.4 (0.3–0.5) | 0.3 (0.1–0.4) | |||||||||||
FN: febrile neutropenia.
*Value (95% CI).