Table 2.
Patient demographics and treatment
| All (N = 1046) No. (%) | Current smokers (N = 242) No. (%) | Former smokers (N = 381) No. (%) | Never smokers (N = 423) No. (%) | p- value | |
|---|---|---|---|---|---|
| Age in years |
|
|
|
|
|
| Mean (range) |
56.2 (28–87) |
55.6 (35 – 80) |
59.3 (36 – 87) |
53.7 (28 – 81) |
.01 |
| Median |
55 |
55 |
58 |
53 |
|
| Sex |
|
|
|
|
.725 |
| Male |
906 (87) |
207 (86) |
334 (88) |
365 (86) |
|
| Female |
140 (13) |
35 (14) |
47 (12) |
58 (14) |
|
| Race |
|
|
|
|
<.001 |
| White |
930 (89) |
197 (21) |
353 (38) |
380 (41) |
|
| Black |
47 (5) |
29 (62) |
3 (6) |
15 (32) |
|
| Hispanic |
55 (5) |
12 (22) |
19 (35) |
24 (44) |
|
| Other |
14 (1) |
5 (36) |
6 (43) |
3 (21) |
|
| Cigarette pack-year |
|
|
|
|
<.001 |
| None |
423 (42) |
|
|
423 (100) |
|
| 1 - 30 |
339 (32) |
86 (36) |
253 (69) |
|
|
| >30 |
265 (26) |
153 (64) |
112 (31) |
|
|
| Primary site |
|
|
|
|
<.001 |
| Tonsil |
460 (44) |
111 (46) |
171 (45) |
178 (42) |
|
| Base of tongue |
511 (49) |
95 (39) |
186 (49) |
230 (54) |
|
| Other* |
75 (7) |
36 (15) |
24 (6) |
15 (4) |
|
| T-category |
|
|
|
|
<.001 |
| 1-2 |
640 (62) |
107 (44) |
235 (62) |
298 (71) |
|
| 3-4 |
406 (38) |
135 (56) |
146 (38) |
125 (30) |
|
| N-category |
|
|
|
|
.07 |
| 0 |
57 (5) |
20 (8) |
22 (6) |
15 (4) |
|
| 1 -2a |
317 (30) |
63 (26) |
120 (31) |
134 (32) |
|
| 2b – 2c |
573 (55) |
128 (53) |
205 (54) |
240 (57) |
|
| 3 |
99 (9) |
31 (13) |
34 (9) |
34 (8) |
|
| Stage |
|
|
|
|
.001 |
| 3 |
206 (20) |
43 (18) |
83 (22) |
80 (19) |
|
| 4A |
707 (68) |
149 (62) |
257 (68) |
30 (72) |
|
| 4B |
133 (13) |
50 (21) |
41 (11) |
42 (10) |
|
| Treatment |
|
|
|
|
.176 |
| XRT alone |
415 (40) |
83 (34) |
158 (42) |
175 (41) |
|
| CTXRT |
389 (37) |
102 (43) |
146 (38) |
141 (33) |
|
| Ind. CTX > XRT |
118 (11) |
29 (12) |
35 (9) |
53 (13) |
|
| Ind. CTX > CTXRT |
124 (12) |
28 (12) |
42 (11) |
54 (14) |
|
| Radiation technique |
|
|
|
|
<.001 |
| IMRT |
714 (69) |
141 (58) |
211 (69) |
316 (75) |
|
| 3D conformal |
328 (31) |
101 (42) |
120 (31) |
107 (25) |
|
| Radiation Fractionation |
|
|
|
|
.442 |
| Once- daily |
700 (67) |
154 (64) |
250 (66) |
296 (70) |
|
| Altered fractionation | 346 (33) | 88 (36) | 131 (34) | 127 (30) |
*Other primary sites: soft palate, 19 patients; pharyngeal wall, 34, NOS (not otherwise specified), 22.
XRT – Radiotherapy; CTXRT – concurrent chemoradiation; Ind. CTX – Induction chemotherapy.