Table 1. Properties of singlish and multiple-interface yeast protein hubs.

Properties	Singlish-interface	Multiple-interface
Essential	No	Yes
Conserved	No	Yes
Co-expression	Limited	High
3D Structure	Smaller, less stable	Larger, stable
Canonical preferential gene duplication	Yes	No
Disorder	High	Low

The properties for each type of interface are listed based on observed tendencies seen in Dataset 3 [16], [28].