Table 2. Properties of date and party yeast protein hubs.

Properties	Date	Party
Evolutionary rate	Faster	Slower
Interactome connectivity	Intermodule	Intramodule
Structural interaction	Few interaction sites	Many interaction sites
Hot spots	More organized in hot regions	Less organized in hot regions
Hot regions	Covers a larger fraction of the interface region, larger number of distinct hot regions	Covers a smaller fraction of the interface region, smaller number of distinct hot regions

The properties for each type of interface are listed based on observed tendencies seen in Dataset 4 [25], [31], [33].