Table 1. Clinicopathological characteristics and Kaplan-Meier cause specific survival (CSS) analysis of SEER hypopharyngeal cancer cases with pathological lymph node involvement.
Variables | No. | 5-year CSS | Log-rank χ2 | P value |
Race | 29.840 | <0.001 | ||
White | 696 | 46.2% | ||
Black | 155 | 26.7% | ||
Other | 65 | 37.5% | ||
Gender | 0.303 | 0.582 | ||
Male | 750 | 41.7% | ||
Female | 166 | 44.8% | ||
Year of diagnosis | 0.156 | 0.925 | ||
1988–1994 | 282 | 42.1% | ||
1995–2001 | 298 | 43.1% | ||
2002–2008 | 336 | 41.4% | ||
Primary site | 17.637 | 0.003 | ||
Pyriform sinus | 664 | 43.2% | ||
Postcricoid region | 20 | 28.7% | ||
Aryepiglottic fold | 25 | 63.4% | ||
Posterior wall | 36 | 42.0% | ||
Overlapping lesion | 24 | 13.8% | ||
Hypopharynx, NOS | 147 | 42.1% | ||
Histological grade | 3.230 | 0.520 | ||
I | 28 | 36.5% | ||
II | 370 | 44.6% | ||
III | 406 | 40.8% | ||
IV | 16 | 0 | ||
Unknown | 96 | 39.9% | ||
Surgery of primary site | 1.317 | 0.725 | ||
None | 216 | 40.0% | ||
Local excision | 92 | 48.4% | ||
Pharyngectomy | 595 | 42.4% | ||
Unknown | 13 | 0 | ||
Radiation sequence | 25.588 | <0.001 | ||
No radiation | 226 | 34.5% | ||
Pre-operative | 50 | 35.1% | ||
Post-operative | 620 | 46.1% | ||
Other | 20 | 0 | ||
Cancer directed surgery | 7.519 | 0.006 | ||
Yes | 747 | 43.2% | ||
Other | 169 | 38.9% | ||
T stage | 38.547 | <0.001 | ||
T1 | 81 | 65.9% | ||
T2 | 152 | 56.1% | ||
T3 | 144 | 39.6% | ||
T4 | 376 | 33.2% | ||
Tx | 163 | 41.8% | ||
N stage | 15.483 | <0.001 | ||
N1 | 194 | 51.4% | ||
N2 | 653 | 41.5% | ||
N3 | 69 | 23.0% | ||
M stage | 46.848 | <0.001 | ||
M0 | 871 | 43.8% | ||
M1 | 31 | 5.4% | ||
Mx | 14 | 24.2% |