Table 3. Univariate and multivariate analysis of the categorical and continuous LNR with cause-specific survival (CSS) and overall survival (OS) of SEER hypopharyngeal cancer patients with lymph node metastasis.
| LNR classification | No. | 5-y CSS(%) | Log-rank χ2 † | HR (95% CI) ‡ | C-index‡ | AIC‡ | 5-y OS(%) | Log-rank χ2 # | HR (95% CIs) * | C-index* | AIC* |
| Continuous LNR | 2.415(1.707–3.416) | 0.688 | 5946.70 | 2.005(1.483–2.712) | 0.668 | 8001.08 | |||||
| Cutpoints 0.09/0.27 | 39.326 | 0.695 | 5943.40 | 28.887 | 0.672 | 7997.18 | |||||
| R1∶0–0.09 | 330 | 51.6 | Reference | 38.9 | Reference | ||||||
| R2∶0.09–0.27 | 285 | 40.9 | 1.451(1.131–1.861) | 30.0 | 1.328(1.076–1.639) | ||||||
| R3: >0.27 | 301 | 32.6 | 2.150(1.631–2.845) | 22.4 | 1.855(1.463–2.353) | ||||||
| Cutpoints 0.08/0.33 | 35.427 | 0.698 | 5937.27 | 37.160 | 0.675 | 7988.71 | |||||
| R1∶0–0.08 | 301 | 52.0 | Reference | 39.5 | Reference | ||||||
| R2∶0.08–0.33 | 357 | 41.9 | 1.523(1.190–1.948) | 30.1 | 1.343(1.090–1.653) | ||||||
| R3: >0.33 | 258 | 30.3 | 2.488(1.848–3.350) | 21.3 | 2.160(1.672–2.790) | ||||||
| Cutpoints 0.05/0.30 | 33.768 | 0.697 | 5934.87 | 33.894 | 0.674 | 7988.71 | |||||
| R1∶0–0.05 | 177 | 55.6 | Reference | 43.1 | Reference | ||||||
| R2∶0.05–0.30 | 458 | 43.6 | 1.686(1.262–2.252) | 31.6 | 1.461(1.151–1.856) | ||||||
| R3: >0.30 | 281 | 30.7 | 2.822(2.011–3.959) | 21.3 | 2.301(1.729–3.062) |
†
The P value for Log-rank χ2 tests of cause specific survival was less than 0.001.
‡
Being calculated using the multivariates Cox regression model for cause specific survival with either continuous or categorical LNR and variates listed at Table 2 as covariates.
#
The P value for Log-rank χ2 tests of overall survival was less than 0.001.
*
Being calculated using the multivariates Cox regression model for overall survival with either continuous or categorical LNR and variates listed at Table 2 as covariates.